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Structure of a strand-swapped dimeric form of ctla-4

Analyse Structure of a strand-swapped dimeric form of ctla-4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2X44
Type: protein
Length: 121 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytotoxic T-lymphocyte protein 4
UniProt: P16410
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	Cytotoxic T-lymphocyte protein 4	protein	121	2% helix, 40% strand	P16410

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.50	0.80	20	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2X44 · Structure of a strand-swapped dimeric form of CTLA-4 · the same entry in another collection · chain D against D, TM-score 1.00
P16410 · AlphaFold monomer V2.0 prediction for cytotoxic T-lymphocyte protein 4 (P16410) · a predicted model of the same protein · chain D against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16410
Elsewhere: RCSB PDB 2X44 · PDBe 2X44 · UniProt P16410

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