Research workbench
Structure of mouse syndapin I (crystal form 1)
Analyse Structure of mouse syndapin I (crystal form 1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2X3X
- Type
- protein
- Length
- 968 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C and casein kinase substrate in neurons protein 1
- UniProt
- Q61644
- Pockets
- 8 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Protein kinase C and casein kinase substrate in neurons protein 1 | protein | 291 | 78% helix, 1% strand | Q61644 |
| B | Protein kinase C and casein kinase substrate in neurons protein 1 | protein | 274 | 78% helix, 1% strand | Q61644 |
| D, E | Protein kinase C and casein kinase substrate in neurons protein 1 | protein | 56 | 5% helix, 41% strand | Q61644 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.59 | 0.81 | 30 | empty |
| 2 | 365 | 0.58 | 0.75 | 40 | empty |
| 3 | 115 | 0.37 | 0.74 | 20 | empty |
| 4 | 81 | 0.35 | 0.76 | 21 | empty |
| 5 | 55 | 0.34 | 0.78 | 10 | empty |
Interfaces
5 interfaces between chains.
- A–B · 4875 Ų buried · 49 hydrogen bonds · protein-protein
- A–D · 519 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 388 Ų buried · 3 hydrogen bonds · protein-protein
- A–E · 369 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 328 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61644
- Elsewhere: RCSB PDB 2X3X · PDBe 2X3X · UniProt Q61644
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