Research workbench

Crystal structure of mouse angiotensinogen in the oxidised form

Analyse Crystal structure of mouse angiotensinogen in the oxidised form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WXX
Type: protein
Length: 1,673 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiotensinogen
UniProt: P11859
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 4 distinct chains · 30% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Angiotensinogen	protein	412	31% helix, 32% strand	P11859
B	Angiotensinogen	protein	428	29% helix, 30% strand	P11859
C	Angiotensinogen	protein	422	31% helix, 31% strand	P11859
D	Angiotensinogen	protein	411	30% helix, 33% strand	P11859

Pockets

20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	854	0.75	0.79	62	empty
2	793	0.75	0.80	59	empty
3	58	0.70	0.97	15	empty
4	158	0.55	0.80	43	empty
5	141	0.53	0.81	36	empty

Interfaces

3 interfaces between chains.

C–D · 613 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 541 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 480 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2WXX · Crystal structure of mouse angiotensinogen in the oxidised form · the same entry in another collection · chain D against D, TM-score 1.00
P11859 · AlphaFold monomer V2.0 prediction for angiotensinogen (P11859) · a predicted model of the same protein · chain D against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11859
Elsewhere: RCSB PDB 2WXX · PDBe 2WXX · UniProt P11859

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.