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Crystal structure of human angiotensinogen

Analyse Crystal structure of human angiotensinogen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WXW
Type: protein
Length: 438 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiotensinogen
UniProt: P01019
Pockets: 6 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Angiotensinogen	protein	438	29% helix, 24% strand	P01019

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.69	0.89	33	empty
2	275	0.57	0.77	28	empty
3	70	0.53	0.86	18	empty
4	152	0.51	0.79	23	empty
5	64	0.31	0.75	17	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2WXW · Crystal structure of human angiotensinogen · the same entry in another collection · chain A against A, TM-score 1.00
P01019 · AlphaFold monomer V2.0 prediction for angiotensinogen (P01019) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01019
Elsewhere: RCSB PDB 2WXW · PDBe 2WXW · UniProt P01019

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