Research workbench
Crystal structure of human glyoxylate reductase hydroxypyruvate reductase
Analyse Crystal structure of human glyoxylate reductase hydroxypyruvate reductase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WWR
- Type
- protein
- Length
- 1,258 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glyoxylate REDUCTASE/HYDROXYPYRUVATE reductase
- EC
- 1.1.1.79
- UniProt
- Q9UBQ7
- Ligands
- MG
- Pockets
- 13 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Glyoxylate REDUCTASE/HYDROXYPYRUVATE reductase (EC 1.1.1.79) | protein | 315 | 39% helix, 18% strand | Q9UBQ7 |
| D | Glyoxylate REDUCTASE/HYDROXYPYRUVATE reductase (EC 1.1.1.79) | protein | 313 | 35% helix, 17% strand | Q9UBQ7 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains B, C, D, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.66 | 0.79 | 52 | empty |
| 2 | 459 | 0.66 | 0.78 | 59 | empty |
| 3 | 432 | 0.66 | 0.79 | 55 | empty |
| 4 | 396 | 0.64 | 0.79 | 44 | empty |
| 5 | 268 | 0.60 | 0.79 | 45 | empty |
Interfaces
4 interfaces between chains.
- C–D · 3252 Ų buried · 28 hydrogen bonds · protein-protein
- A–B · 3180 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 392 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 114 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2WWR · Crystal Structure of Human Glyoxylate Reductase Hydroxypyruvate Reductase · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBQ7 · AlphaFold monomer V2.0 prediction for glyoxylate REDUCTASE/HYDROXYPYRUVATE reductase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBQ7
- Elsewhere: RCSB PDB 2WWR · PDBe 2WWR · UniProt Q9UBQ7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.