Research workbench
Mannosyl-3-phosphoglycerate synthase from thermus thermophilus HB27 apoprotein
Analyse Mannosyl-3-phosphoglycerate synthase from thermus thermophilus HB27 apoprotein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WVK
- Type
- protein
- Length
- 773 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mannosyl-3-phosphoglycerate synthase
- EC
- 2.4.1.217
- UniProt
- Q72K30
- Ligands
- ZN
- Pockets
- 8 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) | protein | 391 | 44% helix, 17% strand | Q72K30 |
| B | Mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) | protein | 382 | 43% helix, 18% strand | Q72K30 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 780 | 0.78 | 0.82 | 56 | empty |
| 2 | 741 | 0.73 | 0.78 | 58 | empty |
| 3 | 388 | 0.62 | 0.77 | 30 | empty |
| 4 | 103 | 0.38 | 0.76 | 17 | empty |
| 5 | 102 | 0.38 | 0.76 | 21 | FLC |
Interfaces
1 interface between chains.
- A–B · 1749 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 2WVK · Mannosyl-3-phosphoglycerate synthase from Thermus thermophilus HB27 apoprotein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72K30
- Elsewhere: RCSB PDB 2WVK · PDBe 2WVK · UniProt Q72K30
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