Research workbench
Crystal structure of the hlyiir mutant protein with residues 169-186 substituted by a linker containing two thrombin sites
Analyse Crystal structure of the hlyiir mutant protein with residues 169-186… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WV1
- Type
- protein
- Length
- 366 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemolysin II regulatory protein
- UniProt
- Q7X506
- Ligands
- NO3
- Pockets
- 4 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemolysin II regulatory protein | protein | 183 | 75% helix, 0% strand | Q7X506 |
| B | Hemolysin II regulatory protein | protein | 183 | 75% helix, 0% strand | Q7X506 |
Ligands and binding sites
- NO3 · Nitrate ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 227 | 0.68 | 0.85 | 35 | empty |
| 2 | 144 | 0.62 | 0.85 | 20 | empty |
| 3 | 105 | 0.44 | 0.78 | 25 | empty |
| 4 | 74 | 0.37 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2026 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2WV1 · Crystal structure of the hlyiir mutant protein with residues 169-186 substituted by a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7X506
- Elsewhere: RCSB PDB 2WV1 · PDBe 2WV1 · UniProt Q7X506
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