Research workbench
Crystal structure of the bzip heterodimeric complex MAFB:CFOS bound to DNA
Analyse Crystal structure of the bzip heterodimeric complex MAFB:CFOS bound to DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WT7
- Type
- protein + DNA
- Length
- 185 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proto-oncogene protein C-fos; Transcription factor mafb; Modified T-mare motif
- UniProt
- P01101, P54841
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 4 distinct chains · 90% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proto-oncogene protein C-fos | protein | 63 | 97% helix, 0% strand | P01101 |
| B | Transcription factor mafb | protein | 90 | 84% helix, 0% strand | P54841 |
| C | Modified T-mare motif | dna | 16 | — | — |
| D | Modified T-mare motif | dna | 16 | — | — |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.66 | 0.83 | 31 | PO4 |
| 2 | 124 | 0.44 | 0.77 | 17 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1105 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 710 Ų buried · 63 hydrogen bonds · nucleic-nucleic
- B–C · 502 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–C · 405 Ų buried · 7 hydrogen bonds · protein-nucleic
- B–D · 335 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 2WT7 · Crystal structure of the bZIP heterodimeric complex MafB:cFos bound to DNA · the same entry in another collection · chain A against A, TM-score 1.00
- P54841 · AlphaFold monomer V2.0 prediction for transcription factor mafb (P54841) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P01101 · AlphaFold monomer V2.0 prediction for proto-oncogene C-fos (P01101) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01101
- Every structure of UniProt P54841
- Elsewhere: RCSB PDB 2WT7 · PDBe 2WT7 · UniProt P01101 · UniProt P54841
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