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Equine rhinitis a virus at low pH

Analyse Equine rhinitis a virus at low pH in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WS9
Type: protein
Length: 693 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: P1
UniProt: B9VV85
Pockets: 12 · best druggability 0.75

Structure

x-ray diffraction · 4 distinct chains · 8% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	P1	protein	246	6% helix, 27% strand	B9VV85
2	P1	protein	200	10% helix, 45% strand	B9VV85
3	P1	protein	226	7% helix, 38% strand	B9VV85
4	P1	protein	21	38% helix, 10% strand	B9VV85

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.75	0.99	17	empty
2	268	0.56	0.77	40	empty
3	88	0.50	0.82	19	empty
4	79	0.46	0.82	18	empty
5	136	0.43	0.75	25	empty

Interfaces

5 interfaces between chains.

1–3 · 3832 Å² buried · 51 hydrogen bonds · protein-protein
2–3 · 1281 Å² buried · 20 hydrogen bonds · protein-protein
1–2 · 1210 Å² buried · 18 hydrogen bonds · protein-protein
3–4 · 647 Å² buried · 7 hydrogen bonds · protein-protein
1–4 · 368 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

2WS9 · Equine Rhinitis A Virus at Low pH · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B9VV85
Elsewhere: RCSB PDB 2WS9 · PDBe 2WS9 · UniProt B9VV85

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