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The novel beta-propeller of the btb-kelch protein KRP1 provides the binding site for lasp-1 that is necessary for pseudopodia extension

Analyse The novel beta-propeller of the btb-kelch protein KRP1 provides the binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WOZ
Type: protein
Length: 307 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kelch repeat and btb domain-containing protein 10
UniProt: Q9ER30
Pockets: 2 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kelch repeat and btb domain-containing protein 10	protein	307	2% helix, 52% strand	Q9ER30

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	842	0.78	0.82	66	empty
2	51	0.49	0.87	14	empty

Compared structures

2WOZ · The novel beta-propeller of the BTB-Kelch protein Krp1 provides the binding site for… · the same entry in another collection · chain A against A, TM-score 1.00
Q9ER30 · AlphaFold monomer V2.0 prediction for kelch-like protein 41 (Q9ER30) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ER30
Elsewhere: RCSB PDB 2WOZ · PDBe 2WOZ · UniProt Q9ER30

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