Research workbench
Crystal structures of holliday junction resolvases from archaeoglobus fulgidus bound to DNA substrate
Analyse Crystal structures of holliday junction resolvases from archaeoglobus fulgidus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WIZ
- Type
- protein + DNA
- Length
- 287 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Archaeal hjc; Half-junction
- UniProt
- O28314
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Archaeal hjc | protein | 125 | 30% helix, 30% strand | O28314 |
| B | Archaeal hjc | protein | 122 | 30% helix, 31% strand | O28314 |
| C | Half-junction | dna | 20 | — | — |
| D | Half-junction | dna | 20 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 333 | 0.63 | 0.80 | 36 | empty |
| 2 | 73 | 0.33 | 0.75 | 11 | empty |
| 3 | 74 | 0.29 | 0.73 | 14 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1029 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 462 Ų buried · 39 hydrogen bonds · nucleic-nucleic
- A–C · 304 Ų buried · 7 hydrogen bonds · protein-nucleic
- A–D · 90 Ų buried · 0 hydrogen bonds · protein-nucleic
- B–D · 51 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
- 2WIZ · Crystal structures of Holliday junction resolvases from Archaeoglobus fulgidus bound to… · the same entry in another collection · chain A against A, TM-score 1.00
- O28314 · AlphaFold monomer V2.0 prediction for holliday junction resolvase hjc (O28314) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O28314
- Elsewhere: RCSB PDB 2WIZ · PDBe 2WIZ · UniProt O28314
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