Atomic resolution crystal structure of the ppiase domain of human cyclophilin G in complex with cyclosporin a.

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 31% strand (DSSP).

Ligands and binding sites

• MG · Magnesium ion · metal · 2 copies · chains A
• CL · Chloride ion · ion · chains A
• EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 484 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified, 1 d-amino (nonstandard, methylation, D-amino acid).

Compared structures

• 2WFJ · Atomic resolution crystal structure of the PPIase domain of human cyclophilin G in… · the same entry in another collection · chain A against A, TM-score 1.00
• Q13427 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase G (Q13427) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q13427
• Elsewhere: RCSB PDB 2WFJ · PDBe 2WFJ · UniProt Q13427