Research workbench
Structure of the candida albicans cytosolic leucyl-tRNA synthetase editing domain
Analyse Structure of the candida albicans cytosolic leucyl-tRNA synthetase editing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2WFE
- Type
- protein
- Length
- 983 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytosolic leucyl-tRNA synthetase
- UniProt
- Q5A9A4
- Pockets
- 14 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 34% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytosolic leucyl-tRNA synthetase | protein | 246 | 34% helix, 25% strand | Q5A9A4 |
| B | Cytosolic leucyl-tRNA synthetase | protein | 250 | 35% helix, 24% strand | Q5A9A4 |
| C | Cytosolic leucyl-tRNA synthetase | protein | 246 | 33% helix, 26% strand | Q5A9A4 |
| D | Cytosolic leucyl-tRNA synthetase | protein | 241 | 34% helix, 26% strand | Q5A9A4 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.70 | 0.82 | 43 | empty |
| 2 | 331 | 0.69 | 0.83 | 35 | empty |
| 3 | 281 | 0.69 | 0.84 | 27 | empty |
| 4 | 331 | 0.67 | 0.81 | 26 | empty |
| 5 | 487 | 0.65 | 0.77 | 39 | empty |
Interfaces
4 interfaces between chains.
- C–D · 740 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 502 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 273 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 90 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2WFE · Structure of the Candida albicans cytosolic leucyl-tRNA synthetase editing domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5A9A4
- Elsewhere: RCSB PDB 2WFE · PDBe 2WFE · UniProt Q5A9A4
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