Research workbench

Crystal structure of mycobacterium tuberculosis RV0376C homologue from mycobacterium smegmatis

Analyse Crystal structure of mycobacterium tuberculosis RV0376C homologue from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WE7
Type: protein
Length: 678 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Xanthine dehydrogenase
EC: 1.17.1.4
UniProt: A0QQG1
Pockets: 11 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Xanthine dehydrogenase (EC 1.17.1.4)	protein	343	34% helix, 25% strand	A0QQG1
B	Xanthine dehydrogenase (EC 1.17.1.4)	protein	335	35% helix, 23% strand	A0QQG1

Pockets

11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	117	0.79	0.97	25	empty
2	85	0.77	0.98	21	empty
3	128	0.64	0.88	28	empty
4	112	0.36	0.74	28	empty
5	93	0.34	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 348 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

2WE7 · Crystal structure of Mycobacterium tuberculosis Rv0376c homologue from Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0QQG1
Elsewhere: RCSB PDB 2WE7 · PDBe 2WE7 · UniProt A0QQG1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.