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Crystal structure of haspin kinase

Analyse Crystal structure of haspin kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WB8
Type: protein
Length: 351 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase haspin
EC: 2.7.11.1
UniProt: Q8TF76
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase haspin (EC 2.7.11.1)	protein	351	41% helix, 22% strand	Q8TF76

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	543	0.70	0.79	66	empty
2	58	0.32	0.77	16	empty

Compared structures

2WB8 · Crystal structure of Haspin kinase · the same entry in another collection · chain A against A, TM-score 1.00
Q8TF76 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase haspin (Q8TF76) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TF76
Elsewhere: RCSB PDB 2WB8 · PDBe 2WB8 · UniProt Q8TF76

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