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Crystal structure of human GADD45GAMMA

Analyse Crystal structure of human GADD45GAMMA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2WAL
Type: protein
Length: 285 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Growth arrest and DNA-damage-inducible protein GADD45 gamma
UniProt: O95257
Pockets: 4 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Growth arrest and DNA-damage-inducible protein GADD45 gamma	protein	149	49% helix, 14% strand	O95257
B	Growth arrest and DNA-damage-inducible protein GADD45 gamma	protein	136	51% helix, 13% strand	O95257

Ligands and binding sites

MLA · Malonic acid · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	190	0.81	0.96	37	empty
2	63	0.69	0.96	16	MLA
3	76	0.64	0.92	23	empty
4	57	0.34	0.78	19	empty

Interfaces

1 interface between chains.

A–B · 1397 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

2WAL · Crystal Structure of human GADD45gamma · the same entry in another collection · chain A against A, TM-score 1.00
O95257 · AlphaFold monomer V2.0 prediction for growth arrest and DNA damage- inducible protein… · a predicted model of the same protein · chain B against A, TM-score 0.94

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Every structure of UniProt O95257
Elsewhere: RCSB PDB 2WAL · PDBe 2WAL · UniProt O95257

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