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The crystal structure of human C340A ssadh

Analyse The crystal structure of human C340A ssadh in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W8P
Type: protein
Length: 485 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Succinic semialdehyde dehydrogenase mitochondrial
EC: 1.2.1.24
UniProt: P51649
Ligands: SO4
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Succinic semialdehyde dehydrogenase mitochondrial (EC 1.2.1.24)	protein	485	41% helix, 21% strand	P51649

Ligands and binding sites

SO4 · Sulfate ion · ion · 8 copies · chains A
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	642	0.72	0.79	70	SO4, GOL
2	105	0.48	0.81	28	empty
3	77	0.34	0.76	15	empty

Compared structures

2W8P · The crystal structure of human C340A SSADH · the same entry in another collection · chain A against A, TM-score 1.00
P51649 · AlphaFold monomer V2.0 prediction for succinate-semialdehyde dehydrogenase, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51649
Elsewhere: RCSB PDB 2W8P · PDBe 2W8P · UniProt P51649

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