Research workbench
Spla serine protease of staphylococcus aureus (1.8A)
Analyse Spla serine protease of staphylococcus aureus (1.8A) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W7S
- Type
- protein
- Length
- 777 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine protease spla
- EC
- 3.4.21.19
- UniProt
- Q2FXC2
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine protease spla (EC 3.4.21.19) | protein | 196 | 14% helix, 39% strand | Q2FXC2 |
| B | Serine protease spla (EC 3.4.21.19) | protein | 195 | 15% helix, 40% strand | Q2FXC2 |
| C | Serine protease spla (EC 3.4.21.19) | protein | 192 | 10% helix, 43% strand | Q2FXC2 |
| D | Serine protease spla (EC 3.4.21.19) | protein | 194 | 8% helix, 41% strand | Q2FXC2 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 834 | 0.78 | 0.81 | 109 | empty |
| 2 | 149 | 0.71 | 0.90 | 34 | empty |
| 3 | 101 | 0.48 | 0.81 | 16 | empty |
| 4 | 89 | 0.45 | 0.80 | 19 | empty |
| 5 | 53 | 0.28 | 0.74 | 16 | empty |
Interfaces
4 interfaces between chains.
- A–B · 588 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 455 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 324 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 203 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2FXC2
- Elsewhere: RCSB PDB 2W7S · PDBe 2W7S · UniProt Q2FXC2
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