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Human NEK2 kinase apo

Analyse Human NEK2 kinase apo in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W5H
Type: protein
Length: 265 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase NEK2
EC: 2.7.11.1
UniProt: P51955
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase NEK2 (EC 2.7.11.1)	protein	265	44% helix, 18% strand	P51955

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	536	0.70	0.79	48	empty
2	169	0.43	0.74	20	empty
3	121	0.41	0.75	18	empty
4	70	0.34	0.75	10	empty

Compared structures

2W5H · Human Nek2 kinase Apo · the same entry in another collection · chain A against A, TM-score 1.00
P51955 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase NEK2 (P51955) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51955
Elsewhere: RCSB PDB 2W5H · PDBe 2W5H · UniProt P51955

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