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Novel RNA-binding domain in cryptosporidium parvum at 2.5 ångström resolution

Analyse Novel RNA-binding domain in cryptosporidium parvum at 2.5 ångström resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W4S
Type: protein
Length: 343 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ankyrin-repeat protein
UniProt: Q7YZ62
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D	Ankyrin-repeat protein	protein	86	73% helix, 2% strand	Q7YZ62
B	Ankyrin-repeat protein	protein	85	72% helix, 5% strand	Q7YZ62

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.41	0.76	16	empty
2	114	0.40	0.75	16	empty

Interfaces

3 interfaces between chains.

A–B · 821 Å² buried · 7 hydrogen bonds · protein-protein
C–D · 808 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 308 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

2W4S · novel RNA-binding domain in Cryptosporidium parvum at 2.5 angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7YZ62
Elsewhere: RCSB PDB 2W4S · PDBe 2W4S · UniProt Q7YZ62

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