Research workbench
Epstein-barr virus alkaline nuclease
Analyse Epstein-barr virus alkaline nuclease in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W45
- Type
- protein
- Length
- 886 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alkaline exonuclease
- EC
- 3.1.11.-
- UniProt
- P03217
- Pockets
- 10 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alkaline exonuclease (EC 3.1.11.-) | protein | 449 | 39% helix, 19% strand | P03217 |
| B | Alkaline exonuclease (EC 3.1.11.-) | protein | 437 | 40% helix, 18% strand | P03217 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1135 | 0.83 | 0.84 | 107 | empty |
| 2 | 365 | 0.55 | 0.74 | 53 | empty |
| 3 | 86 | 0.54 | 0.85 | 17 | empty |
| 4 | 345 | 0.53 | 0.73 | 43 | empty |
| 5 | 134 | 0.52 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1011 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2W45 · Epstein-Barr virus alkaline nuclease · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03217
- Elsewhere: RCSB PDB 2W45 · PDBe 2W45 · UniProt P03217
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