Research workbench
Reduced structure of the first gaf domain of mycobacterium tuberculosis doss
Analyse Reduced structure of the first gaf domain of mycobacterium tuberculosis doss in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W3F
- Type
- protein
- Length
- 292 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two component sensor histidine kinase devs (gaf family protein)
- EC
- 2.7.3.-
- UniProt
- P95194
- Ligands
- HEM
- Pockets
- 5 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Two component sensor histidine kinase devs (gaf family protein) (EC 2.7.3.-) | protein | 148 | 37% helix, 24% strand | P95194 |
| B | Two component sensor histidine kinase devs (gaf family protein) (EC 2.7.3.-) | protein | 144 | 42% helix, 26% strand | P95194 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 328 | 0.79 | 0.89 | 34 | HEM |
| 2 | 313 | 0.77 | 0.88 | 33 | HEM |
| 3 | 63 | 0.37 | 0.78 | 16 | empty |
| 4 | 100 | 0.36 | 0.74 | 19 | empty |
| 5 | 83 | 0.33 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 776 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2W3F · Reduced structure of the first GAF domain of Mycobacterium tuberculosis DosS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P95194
- Elsewhere: RCSB PDB 2W3F · PDBe 2W3F · UniProt P95194
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