Research workbench
Crystal structure of the human carbonic anhydrase related protein VIII
Analyse Crystal structure of the human carbonic anhydrase related protein VIII in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W2J
- Type
- protein
- Length
- 268 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase-related protein
- EC
- 4.2.1.1
- UniProt
- P35219
- Ligands
- CL, UNX
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase-related protein (EC 4.2.1.1) | protein | 268 | 15% helix, 30% strand | P35219 |
Ligands and binding sites
- CL · Chloride ion · ion · 3 copies · chains A
- UNX · Unknown atom or ion · ion · 3 copies · chains A
- GOL · Glycerol · additive · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.49 | 0.83 | 20 | empty |
| 2 | 91 | 0.47 | 0.81 | 19 | CL, UNX |
Compared structures
- 2W2J · Crystal structure of the human carbonic anhydrase related protein VIII · the same entry in another collection · chain A against A, TM-score 1.00
- P35219 · AlphaFold monomer V2.0 prediction for carbonic anhydrase-related protein (P35219) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35219
- Elsewhere: RCSB PDB 2W2J · PDBe 2W2J · UniProt P35219
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