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GLY102THR mutant of RV3291C

Analyse GLY102THR mutant of RV3291C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W29
Type: protein
Length: 588 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable transcriptional regulatory protein
UniProt: P96896
Pockets: 4 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Probable transcriptional regulatory protein	protein	147	39% helix, 30% strand	P96896

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	828	0.80	0.83	106	empty
2	418	0.74	0.84	65	empty
3	444	0.74	0.83	71	empty
4	67	0.29	0.73	12	empty

Interfaces

5 interfaces between chains.

A–B · 3029 Å² buried · 52 hydrogen bonds · protein-protein
C–D · 3018 Å² buried · 53 hydrogen bonds · protein-protein
B–D · 610 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 270 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 214 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

2W29 · Gly102Thr mutant of Rv3291c · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P96896
Elsewhere: RCSB PDB 2W29 · PDBe 2W29 · UniProt P96896

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