Research workbench
Crystal structure of the mutant H8P from the recombinant variable domain 6JAL2
Analyse Crystal structure of the mutant H8P from the recombinant variable domain 6JAL2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W0L
- Type
- protein
- Length
- 444 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- V1-22 protein
- UniProt
- Q5NV88
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | V1-22 protein | protein | 111 | 5% helix, 47% strand | Q5NV88 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 472 | 0.60 | 0.74 | 62 | empty |
| 2 | 131 | 0.42 | 0.75 | 19 | empty |
| 3 | 121 | 0.41 | 0.76 | 21 | empty |
| 4 | 54 | 0.31 | 0.77 | 14 | empty |
| 5 | 60 | 0.28 | 0.74 | 14 | empty |
Interfaces
5 interfaces between chains.
- A–C · 642 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 593 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 338 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 13 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 12 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2W0L · Crystal structure of the mutant H8P from the recombinant variable domain 6JAL2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5NV88
- Elsewhere: RCSB PDB 2W0L · PDBe 2W0L · UniProt Q5NV88
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