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Crystal structure of the guanylyl cyclase CYA2
Analyse Crystal structure of the guanylyl cyclase CYA2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W01
- Type
- protein
- Length
- 1,193 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenylate cyclase
- EC
- 4.6.1.2
- UniProt
- P72951
- Pockets
- 8 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenylate cyclase (EC 4.6.1.2) | protein | 201 | 35% helix, 34% strand | P72951 |
| B, F | Adenylate cyclase (EC 4.6.1.2) | protein | 197 | 35% helix, 35% strand | P72951 |
| C | Adenylate cyclase (EC 4.6.1.2) | protein | 200 | 35% helix, 35% strand | P72951 |
| D, E | Adenylate cyclase (EC 4.6.1.2) | protein | 199 | 36% helix, 34% strand | P72951 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1145 | 0.76 | 0.79 | 102 | empty |
| 2 | 709 | 0.73 | 0.79 | 64 | empty |
| 3 | 726 | 0.72 | 0.79 | 63 | empty |
| 4 | 591 | 0.63 | 0.74 | 58 | empty |
| 5 | 99 | 0.38 | 0.75 | 15 | empty |
Interfaces
10 interfaces between chains.
- C–D · 1808 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1627 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 1621 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 387 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 133 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2W01 · Crystal structure of the guanylyl cyclase Cya2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P72951
- Elsewhere: RCSB PDB 2W01 · PDBe 2W01 · UniProt P72951
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