Crystal structure of the C-terminal calponin homology domain of alpha parvin

Structure

x-ray diffraction · 2 distinct chains · 62% helix, 0% strand (DSSP).

Ligands and binding sites

• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
• GOL · Glycerol · additive · chains A
• MRD · (4R)-2-methylpentane-2,4-diol · additive · chains A, B
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 502 Ų buried · 12 hydrogen bonds · protein-protein

Compared structures

• 2VZC · Crystal structure of the C-terminal calponin homology domain of alpha parvin · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NVD7 · AlphaFold monomer V2.0 prediction for alpha-parvin (Q9NVD7) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NVD7
• Elsewhere: RCSB PDB 2VZC · PDBe 2VZC · UniProt Q9NVD7