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Crystal structure of mammalian fatty acid synthase
Analyse Crystal structure of mammalian fatty acid synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VZ8
- Type
- protein
- Length
- 3,966 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid synthase
- EC
- 2.3.1.85
- UniProt
- A5YV76
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fatty acid synthase (EC 2.3.1.85) | protein | 1962 | 31% helix, 23% strand | A5YV76 |
| B | Fatty acid synthase (EC 2.3.1.85) | protein | 2004 | 31% helix, 23% strand | A5YV76 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 475 | 0.86 | 0.92 | 83 | empty |
| 2 | 793 | 0.81 | 0.84 | 87 | empty |
| 3 | 701 | 0.80 | 0.84 | 74 | empty |
| 4 | 588 | 0.79 | 0.85 | 52 | empty |
| 5 | 644 | 0.78 | 0.84 | 76 | empty |
Interfaces
1 interface between chains.
- A–B · 5684 Ų buried · 81 hydrogen bonds · protein-protein
Compared structures
- 2VZ8 · Crystal Structure of Mammalian Fatty Acid Synthase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5YV76
- Elsewhere: RCSB PDB 2VZ8 · PDBe 2VZ8 · UniProt A5YV76
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