Research workbench
Molecular architecture of the stressosome, a signal integration and transduction hub
Analyse Molecular architecture of the stressosome, a signal integration and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VY9
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-sigma-factor antagonist
- UniProt
- Q2RIF5
- Pockets
- 4 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anti-sigma-factor antagonist | protein | 115 | 43% helix, 17% strand | Q2RIF5 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 212 | 0.55 | 0.78 | 29 | empty |
| 2 | 90 | 0.40 | 0.77 | 18 | empty |
| 3 | 54 | 0.34 | 0.78 | 15 | empty |
| 4 | 53 | 0.28 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 597 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 2VY9 · Molecular architecture of the stressosome, a signal integration and transduction hub · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2RIF5
- Elsewhere: RCSB PDB 2VY9 · PDBe 2VY9 · UniProt Q2RIF5
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