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Crystal structure of an insect inhibitor with a fungal trypsin
Analyse Crystal structure of an insect inhibitor with a fungal trypsin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VU8
- Type
- protein
- Length
- 257 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trypsin; Pacifastin-related serine protease inhibitor
- EC
- 3.4.21.4
- UniProt
- P35049, Q8WQ22
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Trypsin (EC 3.4.21.4) | protein | 224 | 13% helix, 38% strand | P35049 |
| I | Pacifastin-related serine protease inhibitor | protein | 33 | 0% helix, 39% strand | Q8WQ22 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.41 | 0.76 | 30 | empty |
Interfaces
1 interface between chains.
- E–I · 898 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35049
- Every structure of UniProt Q8WQ22
- Elsewhere: RCSB PDB 2VU8 · PDBe 2VU8 · UniProt P35049 · UniProt Q8WQ22
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