Research workbench
Tet repressor class H in complex with 5A,6- anhydrotetracycline-mg
Analyse Tet repressor class H in complex with 5A,6- anhydrotetracycline-mg in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VPR
- Type
- protein
- Length
- 197 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetracycline resistance repressor protein
- UniProt
- Q799E2
- Ligands
- TDC, MG, SO4
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetracycline resistance repressor protein | protein | 197 | 74% helix, 0% strand | Q799E2 |
Ligands and binding sites
- TDC · 5A,6-anhydrotetracycline · ligand · chains A
- MG · Magnesium ion · metal · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 298 | 0.65 | 0.81 | 33 | TDC, MG |
| 2 | 63 | 0.29 | 0.74 | 13 | empty |
Compared structures
- 2VPR · Tet repressor class H in complex with 5a,6- anhydrotetracycline-Mg · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q799E2
- Elsewhere: RCSB PDB 2VPR · PDBe 2VPR · UniProt Q799E2
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