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Crystal structure of apo L-alanine dehydrogenase from mycobacterium tuberculosis

Analyse Crystal structure of apo L-alanine dehydrogenase from mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2VHY
Type: protein
Length: 654 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alanine dehydrogenase
EC: 1.4.1.1
UniProt: P30234
Pockets: 6 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alanine dehydrogenase (EC 1.4.1.1)	protein	324	39% helix, 18% strand	P30234
B	Alanine dehydrogenase (EC 1.4.1.1)	protein	330	42% helix, 16% strand	P30234

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	194	0.45	0.74	26	empty
2	162	0.45	0.75	26	empty
3	87	0.40	0.78	25	empty
4	74	0.39	0.78	15	empty
5	60	0.32	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 1790 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

2VHY · Crystal structure of apo L-alanine dehydrogenase from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30234
Elsewhere: RCSB PDB 2VHY · PDBe 2VHY · UniProt P30234

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