Research workbench
Crystal structure of the F96H mutant of plasmodium falciparum triosephosphate isomerase
Analyse Crystal structure of the F96H mutant of plasmodium falciparum triosephosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VFF
- Type
- protein
- Length
- 493 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Triosephosphate isomerase
- EC
- 5.3.1.1
- UniProt
- Q07412
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Triosephosphate isomerase (EC 5.3.1.1) | protein | 247 | 44% helix, 17% strand | Q07412 |
| B | Triosephosphate isomerase (EC 5.3.1.1) | protein | 246 | 44% helix, 16% strand | Q07412 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 109 | 0.77 | 0.97 | 27 | empty |
| 2 | 84 | 0.58 | 0.88 | 22 | empty |
| 3 | 92 | 0.42 | 0.78 | 20 | empty |
| 4 | 78 | 0.41 | 0.79 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1732 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 2VFF · Crystal structure of the F96H mutant of Plasmodium falciparum triosephosphate isomerase · the same entry in another collection · chain A against A, TM-score 1.00
- Q07412 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (Q07412) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07412
- Elsewhere: RCSB PDB 2VFF · PDBe 2VFF · UniProt Q07412
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