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Feast or famine regulatory protein (RV3291C)FROM M. tuberculosis complexed with L-phenylalanine

Analyse Feast or famine regulatory protein (RV3291C)FROM M. tuberculosis complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2VBX
Type: protein
Length: 294 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulatory protein
UniProt: P96896
Ligands: HIS
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transcriptional regulatory protein	protein	147	38% helix, 30% strand	P96896

Ligands and binding sites

HIS · Histidine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	442	0.71	0.82	68	empty
2	159	0.67	0.87	23	HIS
3	53	0.26	0.73	13	empty

Interfaces

1 interface between chains.

A–B · 2937 Å² buried · 58 hydrogen bonds · protein-protein

Compared structures

2VBX · Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P96896
Elsewhere: RCSB PDB 2VBX · PDBe 2VBX · UniProt P96896

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