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Crystal structure of the 70-kda heat shock cognate protein from rattus norvegicus in post-ATP hydrolysis state
Analyse Crystal structure of the 70-kda heat shock cognate protein from rattus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V7Z
- Type
- protein
- Length
- 762 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock cognate 71 kda protein
- UniProt
- Q4FZY7
- Ligands
- ADP, PO4
- Pockets
- 6 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Heat shock cognate 71 kda protein | protein | 381 | 39% helix, 28% strand | Q4FZY7 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1018 | 0.81 | 0.82 | 101 | ADP, PO4 |
| 2 | 714 | 0.77 | 0.82 | 75 | ADP, PO4 |
| 3 | 98 | 0.49 | 0.82 | 28 | empty |
| 4 | 103 | 0.46 | 0.80 | 26 | empty |
| 5 | 63 | 0.46 | 0.83 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 485 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2V7Z · Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4FZY7
- Elsewhere: RCSB PDB 2V7Z · PDBe 2V7Z · UniProt Q4FZY7
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