Research workbench
Crystal structure of sulfolobus solfataricus 2-keto-3- deoxygluconate kinase
Analyse Crystal structure of sulfolobus solfataricus 2-keto-3- deoxygluconate kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V78
- Type
- protein
- Length
- 933 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructokinase
- EC
- 2.7.1.4
- UniProt
- Q97U29
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Fructokinase (EC 2.7.1.4) | protein | 311 | 43% helix, 24% strand | Q97U29 |
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 824 | 0.75 | 0.79 | 71 | empty |
| 2 | 675 | 0.72 | 0.79 | 62 | empty |
| 3 | 517 | 0.70 | 0.80 | 48 | empty |
| 4 | 518 | 0.69 | 0.79 | 50 | empty |
| 5 | 632 | 0.64 | 0.74 | 73 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1134 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 662 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 259 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2V78 · Crystal structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase · the same entry in another collection · chain A against A, TM-score 1.00
- Q97U29 · AlphaFold monomer V2.0 prediction for 2-dehydro-3-DEOXYGLUCONOKINASE/2-dehydro-3-deoxygala… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97U29
- Elsewhere: RCSB PDB 2V78 · PDBe 2V78 · UniProt Q97U29
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