Research workbench
Structure of progesterone 5BETA-reductase from digitalis lanata in complex with NADP
Analyse Structure of progesterone 5BETA-reductase from digitalis lanata in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V6G
- Type
- protein
- Length
- 364 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Progesterone 5-beta-reductase
- UniProt
- Q6PQJ9
- Ligands
- NAP, NA, CL
- Pockets
- 2 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Progesterone 5-beta-reductase | protein | 364 | 41% helix, 13% strand | Q6PQJ9 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.82 | 0.88 | 70 | NAP, CL |
| 2 | 217 | 0.67 | 0.84 | 26 | empty |
Compared structures
- 2V6G · Structure of Progesterone 5beta-Reductase from Digitalis Lanata in complex with NADP · the same entry in another collection · chain A against A, TM-score 1.00
- Q6PQJ9 · AlphaFold monomer V2.0 prediction for 3-oxo-DELTA(4,5)-steroid 5-beta-reductase (Q6PQJ9) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PQJ9
- Elsewhere: RCSB PDB 2V6G · PDBe 2V6G · UniProt Q6PQJ9
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