Research workbench
Structure of the cold active phenylalanine hydroxylase from colwellia psychrerythraea 34H
Analyse Structure of the cold active phenylalanine hydroxylase from colwellia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V27
- Type
- protein
- Length
- 536 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine hydroxylase
- EC
- 1.14.16.1
- UniProt
- Q47XN7
- Ligands
- FE, SO4
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine hydroxylase (EC 1.14.16.1) | protein | 264 | 52% helix, 11% strand | Q47XN7 |
| B | Phenylalanine hydroxylase (EC 1.14.16.1) | protein | 272 | 51% helix, 10% strand | Q47XN7 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.79 | 0.90 | 45 | empty |
| 2 | 512 | 0.74 | 0.82 | 41 | empty |
| 3 | 333 | 0.66 | 0.81 | 31 | empty |
| 4 | 150 | 0.45 | 0.75 | 17 | empty |
| 5 | 118 | 0.35 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 930 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2V27 · Structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea 34H · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q47XN7
- Elsewhere: RCSB PDB 2V27 · PDBe 2V27 · UniProt Q47XN7
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