Research workbench
Crystal structure of rat TOM20-aldh presequence complex
Analyse Crystal structure of rat TOM20-aldh presequence complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V1T
- Type
- protein
- Length
- 167 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial import receptor subunit TOM20 homolog; Aldehyde dehydrogenase
- EC
- 1.2.1.3
- UniProt
- Q62760, P11884
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 3 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial import receptor subunit TOM20 homolog | protein | 73 | 78% helix, 0% strand | Q62760 |
| B | Mitochondrial import receptor subunit TOM20 homolog | protein | 68 | 74% helix, 0% strand | Q62760 |
| C, D | Aldehyde dehydrogenase (EC 1.2.1.3) | protein | 13 | 77% helix, 0% strand | P11884 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.39 | 0.74 | 25 | empty |
| 2 | 57 | 0.35 | 0.78 | 12 | empty |
Interfaces
4 interfaces between chains.
- A–B · 613 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 545 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 523 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 130 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered, nonstandard).
Compared structures
- 2V1T · Crystal structure of rat TOM20-aldh presequence complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q62760 · AlphaFold monomer V2.0 prediction for mitochondrial import receptor subunit TOM20 homolog… · a predicted model of the same protein · chain B against A, TM-score 0.81
- P11884 · AlphaFold monomer V2.0 prediction for aldehyde dehydrogenase, mitochondrial (P11884) · a predicted model of the same protein · chain C against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62760
- Every structure of UniProt P11884
- Elsewhere: RCSB PDB 2V1T · PDBe 2V1T · UniProt Q62760 · UniProt P11884
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