Research workbench
Crystal structure and mutational study of recor provide insight into its role in DNA repair
Analyse Crystal structure and mutational study of recor provide insight into its role… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V1C
- Type
- protein
- Length
- 625 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recombination protein recr; Hypothetical protein
- UniProt
- Q9ZNA2, Q9RW50
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Recombination protein recr | protein | 198 | 41% helix, 14% strand | Q9ZNA2 |
| C | Hypothetical protein | protein | 229 | 38% helix, 19% strand | Q9RW50 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 481 | 0.67 | 0.79 | 60 | empty |
| 2 | 55 | 0.40 | 0.81 | 15 | empty |
| 3 | 91 | 0.36 | 0.75 | 19 | empty |
| 4 | 65 | 0.33 | 0.76 | 20 | empty |
| 5 | 58 | 0.30 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2233 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 909 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 206 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2V1C · Crystal structure and mutational study of RecOR provide insight into its role in DNA… · the same entry in another collection · chain C against C, TM-score 1.00
- Q9ZNA2 · AlphaFold monomer V2.0 prediction for recombination protein recr (Q9ZNA2) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9ZNA2
- Every structure of UniProt Q9RW50
- Elsewhere: RCSB PDB 2V1C · PDBe 2V1C · UniProt Q9ZNA2 · UniProt Q9RW50
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