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Structure of the H61T mutant of the flavoenzyme vanillyl-alcohol oxidase in the apo form

Analyse Structure of the H61T mutant of the flavoenzyme vanillyl-alcohol oxidase in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1E8F
Type: protein
Length: 1,090 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vanillyl-alcohol oxidase
EC: 1.1.3.7
UniProt: P56216
Pockets: 12 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Vanillyl-alcohol oxidase (EC 1.1.3.7)	protein	545	38% helix, 18% strand	P56216

Pockets

12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	758	0.86	0.89	73	empty
2	1108	0.86	0.86	112	empty
3	732	0.85	0.89	75	empty
4	102	0.43	0.78	28	empty
5	94	0.40	0.77	25	empty

Interfaces

1 interface between chains.

A–B · 4211 Å² buried · 47 hydrogen bonds · protein-protein

Compared structures

1E8F · Structure of the H61T mutant of the flavoenzyme vanillyl-alcohol oxidase in the apo form · the same entry in another collection · chain A against A, TM-score 1.00
P56216 · AlphaFold monomer V2.0 prediction for vanillyl-alcohol oxidase (P56216) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P56216
Elsewhere: RCSB PDB 1E8F · PDBe 1E8F · UniProt P56216

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