Research workbench
Structure of the complex of antibody MN423 with a fragment of tau protein
Analyse Structure of the complex of antibody MN423 with a fragment of tau protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V17
- Type
- protein
- Length
- 442 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptide fragment; Monoclonal antibody Fab fragment MN423
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptide fragment | protein | 6 | 0% helix, 0% strand | — |
| H | Monoclonal antibody Fab fragment MN423 | protein | 222 | 7% helix, 51% strand | — |
| L | Monoclonal antibody Fab fragment MN423 | protein | 214 | 7% helix, 49% strand | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 536 | 0.60 | 0.74 | 67 | empty |
| 2 | 174 | 0.51 | 0.78 | 24 | empty |
| 3 | 71 | 0.35 | 0.77 | 17 | empty |
| 4 | 74 | 0.31 | 0.74 | 18 | empty |
| 5 | 53 | 0.26 | 0.73 | 14 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1870 Ų buried · 14 hydrogen bonds · protein-protein
- A–L · 243 Ų buried · 4 hydrogen bonds · protein-protein
- A–H · 228 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2V17 · Structure of the complex of antibody MN423 with a fragment of tau protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2V17 · PDBe 2V17
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