Research workbench
Crystal structure of apo glutamine synthetase from dog ( canis familiaris)
Analyse Crystal structure of apo glutamine synthetase from dog ( canis familiaris) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2UU7
- Type
- protein
- Length
- 5,550 residues
- Chains
- 15
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamine synthetase
- EC
- 6.3.1.2
- UniProt
- Q8HZM5
- Ligands
- MG, CL
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O | Glutamine synthetase (EC 6.3.1.2) | protein | 370 | 29% helix, 25% strand | Q8HZM5 |
Ligands and binding sites
- MG · Magnesium ion · metal · 15 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
- CL · Chloride ion · ion · 15 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 762 | 0.76 | 0.81 | 109 | empty |
| 2 | 1019 | 0.76 | 0.78 | 163 | empty |
| 3 | 687 | 0.76 | 0.81 | 87 | MG |
| 4 | 674 | 0.75 | 0.81 | 80 | MG |
| 5 | 626 | 0.75 | 0.82 | 71 | MG |
Interfaces
26 interfaces between chains.
- L–M · 2158 Ų buried · 33 hydrogen bonds · protein-protein
- F–G · 2157 Ų buried · 33 hydrogen bonds · protein-protein
- G–H · 2151 Ų buried · 33 hydrogen bonds · protein-protein
- N–O · 2150 Ų buried · 32 hydrogen bonds · protein-protein
- I–J · 2148 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 2UU7 · Crystal structure of apo glutamine synthetase from dog (Canis familiaris) · the same entry in another collection · chain O against O, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8HZM5
- Elsewhere: RCSB PDB 2UU7 · PDBe 2UU7 · UniProt Q8HZM5
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