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Smc head domain from thermotoga maritima

Analyse Smc head domain from thermotoga maritima in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1E69
Type: protein
Length: 1,578 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chromosome segregation smc protein
UniProt: Q9X0R4
Pockets: 10 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Chromosome segregation smc protein	protein	263	28% helix, 30% strand	Q9X0R4

Pockets

10 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	164	0.50	0.78	36	empty
2	193	0.48	0.75	23	empty
3	174	0.47	0.76	28	empty
4	164	0.43	0.75	28	empty
5	125	0.39	0.74	24	empty

Interfaces

5 interfaces between chains.

E–F · 650 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 627 Å² buried · 7 hydrogen bonds · protein-protein
C–D · 606 Å² buried · 8 hydrogen bonds · protein-protein
D–E · 595 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 565 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1E69 · SMC head domain from Thermotoga maritima · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X0R4
Elsewhere: RCSB PDB 1E69 · PDBe 1E69 · UniProt Q9X0R4

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