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Structure of apo adenylate kinase from aquifex aeolicus

Analyse Structure of apo adenylate kinase from aquifex aeolicus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RH5
Type: protein
Length: 606 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Adenylate kinase
EC: 2.7.4.3
UniProt: O66490
Pockets: 3 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, B	Adenylate kinase (EC 2.7.4.3)	protein	202	52% helix, 15% strand	O66490

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1038	0.81	0.82	100	empty
2	52	0.34	0.78	13	empty
3	73	0.31	0.74	13	empty

Interfaces

2 interfaces between chains.

C–B · 968 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 30 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2RH5 · Structure of Apo Adenylate Kinase from Aquifex Aeolicus · the same entry in another collection · chain A against A, TM-score 1.00
O66490 · AlphaFold monomer V2.0 prediction for adenylate kinase (O66490) · a predicted model of the same protein · chain A against A, TM-score 0.71

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O66490
Elsewhere: RCSB PDB 2RH5 · PDBe 2RH5 · UniProt O66490

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