Research workbench
Crystal structure of LHX3 lim domains 1 and 2 with the binding domain of ISL1
Analyse Crystal structure of LHX3 lim domains 1 and 2 with the binding domain of ISL1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2RGT
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion of LIM/HOMEOBOX protein LHX3, linker, insulin gene enhancer protein isl-1
- UniProt
- P50481, P61372
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion of LIM/HOMEOBOX protein LHX3, linker, insulin gene enhancer protein isl-1 | protein | 148 | 14% helix, 26% strand | P50481, P61372 |
| B | Fusion of LIM/HOMEOBOX protein LHX3, linker, insulin gene enhancer protein isl-1 | protein | 154 | 12% helix, 33% strand | P50481, P61372 |
Ligands and binding sites
- ZN · Zinc ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.39 | 0.74 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 283 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2RGT · Crystal Structure of Lhx3 LIM domains 1 and 2 with the binding domain of Isl1 · the same entry in another collection · chain A against A, TM-score 1.00
- P61372 · AlphaFold monomer V2.0 prediction for insulin gene enhancer protein isl-1 (P61372) · a predicted model of the same protein · chain B against A, TM-score 0.87
- P50481 · AlphaFold monomer V2.0 prediction for LIM/HOMEOBOX protein LHX3 (P50481) · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50481
- Every structure of UniProt P61372
- Elsewhere: RCSB PDB 2RGT · PDBe 2RGT · UniProt P50481 · UniProt P61372
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