Research workbench
Crystal structure of cellobiohydrolase from melanocarpus albomyces complexed with cellotetraose
Analyse Crystal structure of cellobiohydrolase from melanocarpus albomyces complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2RG0
- Type
- protein
- Length
- 1,720 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellulose 1,4-beta-cellobiosidase
- EC
- 3.2.1.91
- UniProt
- Q8J0K6
- Ligands
- BGC
- Pockets
- 13 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cellulose 1,4-beta-cellobiosidase (EC 3.2.1.91) | protein | 430 | 11% helix, 30% strand | Q8J0K6 |
Ligands and binding sites
- BGC · beta-D-glucopyranose · sugar · 14 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1050 | 0.86 | 0.86 | 95 | BGC |
| 2 | 906 | 0.84 | 0.86 | 90 | BGC |
| 3 | 907 | 0.83 | 0.85 | 97 | BGC |
| 4 | 694 | 0.83 | 0.87 | 77 | BGC |
| 5 | 91 | 0.68 | 0.92 | 26 | empty |
Interfaces
4 interfaces between chains.
- A–D · 911 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 874 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 305 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 284 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 disulfide, 4 modified (disulfide, cyclization).
Compared structures
- 2RG0 · Crystal structure of cellobiohydrolase from Melanocarpus albomyces complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8J0K6
- Elsewhere: RCSB PDB 2RG0 · PDBe 2RG0 · UniProt Q8J0K6
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