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Solution structure of human immunoglobulin M

Analyse Solution structure of human immunoglobulin M in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2RCJ
Type: protein
Length: 7,514 residues
Chains: 21
Method: solution scattering
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: IGA1 light chain; IGA1 heavy chain; J chain
Pockets: 20 · best druggability 0.39

Structure

solution scattering · 3 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, E, F, I, J, M, N, Q, R	IGA1 light chain	protein	218	0% helix, 0% strand	—
C, D, G, H, K, L, O, P, S, T	IGA1 heavy chain	protein	523	0% helix, 0% strand	—
U	J chain	protein	104	0% helix, 0% strand	—

Pockets

20 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.39	0.72	31	empty
2	115	0.38	0.72	33	empty
3	112	0.38	0.72	32	empty
4	92	0.37	0.73	23	empty
5	100	0.37	0.73	23	empty

Interfaces

26 interfaces between chains.

P–S · 295 Å² buried · 0 hydrogen bonds · protein-protein
H–K · 206 Å² buried · 0 hydrogen bonds · protein-protein
L–U · 176 Å² buried · 0 hydrogen bonds · protein-protein
C–T · 167 Å² buried · 0 hydrogen bonds · protein-protein
O–U · 163 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2RCJ · Solution structure of human Immunoglobulin M · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2RCJ · PDBe 2RCJ

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