Research workbench
Crystal form B1
Analyse Crystal form B1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R6D
- Type
- protein
- Length
- 2,340 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicative helicase
- UniProt
- Q9X4C9
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replicative helicase | protein | 405 | 52% helix, 14% strand | Q9X4C9 |
| B, D | Replicative helicase | protein | 376 | 49% helix, 15% strand | Q9X4C9 |
| C | Replicative helicase | protein | 399 | 50% helix, 13% strand | Q9X4C9 |
| E, F | Replicative helicase | protein | 392 | 48% helix, 14% strand | Q9X4C9 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 811 | 0.77 | 0.81 | 74 | empty |
| 2 | 748 | 0.76 | 0.81 | 73 | empty |
| 3 | 812 | 0.74 | 0.78 | 73 | empty |
| 4 | 861 | 0.71 | 0.76 | 75 | empty |
| 5 | 775 | 0.70 | 0.77 | 76 | empty |
Interfaces
9 interfaces between chains.
- A–F · 2613 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 2503 Ų buried · 17 hydrogen bonds · protein-protein
- D–E · 1929 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 1597 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1575 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2R6D · Crystal Form B1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X4C9
- Elsewhere: RCSB PDB 2R6D · PDBe 2R6D · UniProt Q9X4C9
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