Research workbench
Crystal structure of the human BETA2 adrenoceptor
Analyse Crystal structure of the human BETA2 adrenoceptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R4R
- Type
- protein
- Length
- 647 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-2 adrenergic receptor; Antibody for BETA2 adrenoceptor, light chain; Antibody for…
- UniProt
- P07550
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 23% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-2 adrenergic receptor | protein | 216 | 60% helix, 0% strand | P07550 |
| L | Antibody for BETA2 adrenoceptor, light chain | protein | 214 | 7% helix, 42% strand | — |
| H | Antibody for BETA2 adrenoceptor, heavy chain | protein | 217 | 1% helix, 44% strand | — |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 285 | 0.71 | 0.85 | 38 | empty |
| 2 | 768 | 0.68 | 0.75 | 60 | empty |
| 3 | 224 | 0.56 | 0.78 | 29 | empty |
| 4 | 141 | 0.50 | 0.79 | 21 | empty |
| 5 | 160 | 0.46 | 0.75 | 26 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1867 Ų buried · 16 hydrogen bonds · protein-protein
- A–H · 483 Ų buried · 8 hydrogen bonds · protein-protein
- A–L · 375 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07550
- Elsewhere: RCSB PDB 2R4R · PDBe 2R4R · UniProt P07550
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.